SickKids wordmark


Specify your query sequence

Entering sequence into this window and clicking the "run TM Finder" button will run the TM-Finder program (originally written by Dr. Charles Deber and Chen Wang) on the sequence you entered.

To enter your sequence, you can either type it in the "Sequence" form or "cut" and "paste" it from a source or enter the name of the sequence file in the "Sequence File" box below.

N-terminal window: C-terminal window:
Minimum core length: Close gaps of length:
Minimum segment length:

Sequence File:

To turn off segment post processing on the TM predictions, set it to close gaps of length "0" and set the minimum segment size to "1".


Liu, L.-P. and Deber, C.M.: Guidelines for Membrane Protein Engineering Derived from de novo Designed Model Peptides. Biopolymers (Peptide Science) 47, 41-62 (1998). (Abstract)

Liu, L.-P. and Deber, C.M.: Uncoupling Protein Hydrophobicity and Helicity in Nonpolar Environments. J. Biol. Chem 273, 23645-23648 (1998). (Abstract)

Liu, L.-P. and Deber, C.M.: Combining Hydrophobicity and Helicity: A Novel Approach to Membrane Protein Structure Prediction. Bioorg & Med. Chem.7, 1-7 (1999). (Abstract)

Experiencing problems with this web tool? Contact